Larry Gonick asks what I consider this analysis article, Association between low density lipoprotein cholesterol and all-cause mortality: results from the NHANES 1999–2014.
The subject is related to me, as I’ve had ldl cholesterol points. And right here’s a shocking bit from the summary:
We used the 1999–2014 Nationwide Well being and Diet Examination Survey (NHANES) information with 19,034 folks to evaluate the affiliation between LDL-C degree and all-cause mortality. . . . Within the age-adjusted mannequin (mannequin 1), it was discovered that the bottom LDL-C group had a better threat of all-cause mortality (HR 1.7 [1.4–2.1]) than LDL-C 100–129 mg/dL as a reference group. The crude-adjusted mannequin (mannequin 2) suggests that folks with the bottom degree of LDL-C had 1.6 (95% CI [1.3–1.9]) instances the percentages in contrast with the reference group, after adjusting for age, intercourse, race, marital standing, schooling degree, smoking standing, physique mass index (BMI). Within the fully-adjusted mannequin (mannequin 3), folks with the bottom degree of LDL-C had 1.4 (95% CI [1.1–1.7]) instances the percentages in contrast with the reference group, after moreover adjusting for hypertension, diabetes, heart problems, most cancers based mostly on mannequin 2. . . . In conclusion, we discovered that low degree of LDL-C is related to larger threat of all-cause mortality.
The above citation is actual besides that I rounded all numbers to at least one decimal place. The unique model introduced them to 3 decimals (“1.708,” and so on.) and that made me cry.
In any case, the discovering shocked me. I don’t know that it’s really a medical shock; I simply had the overall impression that ldl cholesterol is a foul factor to have. Additionally, I used to be gonna say I used to be shocked that the estimated results have been so giant, however then I noticed the big widths of the boldness intervals, and that shocked me too at first, however then I spotted that not so many individuals within the longitudinal research would have died in the course of the interval, so the efficient pattern dimension isn’t fairly as giant because it may appear at first.
The researchers additionally match some curves:
Subsequent, the inferences that the curve got here from:
The information are in keeping with excessive dangers at low levels of cholesterol and nothing taking place at excessive ranges, additionally in keeping with different patterns, as might be seen from the uncertainty traces.
The printed paper does a great job of presenting information and conclusions clearly with none overclaiming that I can see.
Anyway, I don’t actually know what to make of this research, and I do know nothing in regards to the literature within the space. I’ll nonetheless go by my traditional algorithm and simply belief my physician on every thing.
I’m posting as a result of (a) I simply assume it’s cool that the writer of the Cartoon Information to Statistics reads our weblog, and (b) it may be useful to our readers to see an instance of my ignorance.
Larry Gonick asks what I consider this analysis article, Association between low density lipoprotein cholesterol and all-cause mortality: results from the NHANES 1999–2014.
The subject is related to me, as I’ve had ldl cholesterol points. And right here’s a shocking bit from the summary:
We used the 1999–2014 Nationwide Well being and Diet Examination Survey (NHANES) information with 19,034 folks to evaluate the affiliation between LDL-C degree and all-cause mortality. . . . Within the age-adjusted mannequin (mannequin 1), it was discovered that the bottom LDL-C group had a better threat of all-cause mortality (HR 1.7 [1.4–2.1]) than LDL-C 100–129 mg/dL as a reference group. The crude-adjusted mannequin (mannequin 2) suggests that folks with the bottom degree of LDL-C had 1.6 (95% CI [1.3–1.9]) instances the percentages in contrast with the reference group, after adjusting for age, intercourse, race, marital standing, schooling degree, smoking standing, physique mass index (BMI). Within the fully-adjusted mannequin (mannequin 3), folks with the bottom degree of LDL-C had 1.4 (95% CI [1.1–1.7]) instances the percentages in contrast with the reference group, after moreover adjusting for hypertension, diabetes, heart problems, most cancers based mostly on mannequin 2. . . . In conclusion, we discovered that low degree of LDL-C is related to larger threat of all-cause mortality.
The above citation is actual besides that I rounded all numbers to at least one decimal place. The unique model introduced them to 3 decimals (“1.708,” and so on.) and that made me cry.
In any case, the discovering shocked me. I don’t know that it’s really a medical shock; I simply had the overall impression that ldl cholesterol is a foul factor to have. Additionally, I used to be gonna say I used to be shocked that the estimated results have been so giant, however then I noticed the big widths of the boldness intervals, and that shocked me too at first, however then I spotted that not so many individuals within the longitudinal research would have died in the course of the interval, so the efficient pattern dimension isn’t fairly as giant because it may appear at first.
The researchers additionally match some curves:
Subsequent, the inferences that the curve got here from:
The information are in keeping with excessive dangers at low levels of cholesterol and nothing taking place at excessive ranges, additionally in keeping with different patterns, as might be seen from the uncertainty traces.
The printed paper does a great job of presenting information and conclusions clearly with none overclaiming that I can see.
Anyway, I don’t actually know what to make of this research, and I do know nothing in regards to the literature within the space. I’ll nonetheless go by my traditional algorithm and simply belief my physician on every thing.
I’m posting as a result of (a) I simply assume it’s cool that the writer of the Cartoon Information to Statistics reads our weblog, and (b) it may be useful to our readers to see an instance of my ignorance.